Gastrointestinal Damage from Nonsteroidal Anti-Inflammatory Drugs
نویسندگان
چکیده
منابع مشابه
Nonsteroidal anti-inflammatory drugs.
Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
متن کاملGastrointestinal and cardiovascular risks of nonsteroidal anti-inflammatory drugs.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed but can have serious gastrointestinal (GI) and cardiovascular side effects, which have led to the withdrawal of some of these drugs and continuing uncertainty about the best approach to patients requiring NSAID therapy, particularly in those with GI or cardiovascular risk factors. To define the risks to the GI and cardiovascula...
متن کاملNonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage
NSAIDs are among the most commonly used drugs worldwide and their beneficial therapeutic properties are thoroughly accepted. However, they are also associated with gastrointestinal (GI) adverse events. NSAIDs can damage the whole GI tract including a wide spectrum of lesions. About 1 to 2% of NSAID users experienced a serious GI complication during treatment. The relative risk of upper GI compl...
متن کاملNonsteroidal anti-inflammatory drugs in orthopaedics.
It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
متن کاملNonsteroidal Anti-Inflammatory Drugs and the Kidney
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly pa...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1988
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262338801600218